Here is a complete list of the ingredients contained in Papillex®

Research suggests that supplementing with high-potency clinically-researched nutrients can help provide additional support in optimizing the immune system's response.

Lycopene & Carotenoids

Studies have shown that those with deficient levels of carotenoids have an increased risk of persistent HPV infections.(1) High levels of vegetable consumption have been shown to decrease HPV persistence by more than 50%.(2) Higher levels of lycopene are associated with decreased risks.(2) This shows the importance of loading up on richly-pigmented vegetables such as peppers, tomatoes, carrots, mangos, sweet potatoes, spinach and kale to support overall balance.

A daily serving of Papillex® contains the equivalent of 3/4 cup of frozen cooked spinach, 3 cups of raw carrots, or 2.5 cups of raw cantaloupe daily.(1)

Science & Sources Behind This*
  • Calculation: 8000IU x 2= 16000IU), 3mg of betacarotene is 5000 IU, need 9.6mg. Source
  • 1 Peterson, Caryn E., et al. “Combined antioxidant carotenoids and the risk of persistent human papillomavirus infection.” Nutrition and cancer 62.6 (2010): 728-733. Source
  • 2 Tomita LY, Filho AL, Costa MC, Andreoli MA, Villa LL, Franco EL, Cardoso MA. Diet and serum micronutrients in relation to cervical neoplasia and cancer among low‐income Brazilian women. International journal of cancer. 2010 Feb 1;126(3):703-14. Source

Broccoli Sprout Extract

Indole-3-carbinol, DIM, and sulforaphane are powerful metabolites found in broccoli family vegetables that support the body in the repair of DNA damage and have been shown to lower risks.(3) (4) (5) These important ingredients are found in cabbage, broccoli, broccoli sprouts, brussels sprouts, cauliflower and kale.

To garner the same nutrient benefit as a daily serving of Papillex®, you would need to eat 1 head of broccoli, 2 cups of Brussels sprouts, or 2.8 cups of raw cabbage per day.

Science & Sources Behind This*
  • Calculation: 200mg*2 = 400mg. Source 1 Source 2
  • 3 Higdon, Jane V., et al. “Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.” Pharmacological Research 55.3 (2007): 224-236. Source
  • 4 Lenzi, Monia, Carmela Fimognari, and Patrizia Hrelia. “Sulforaphane as a promising molecule for fighting cancer.” Advances in Nutrition and Cancer. Springer Berlin Heidelberg, 2014. 207-223. Source
  • 5 Li, Yanyan, and Tao Zhang. “Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts.” Future Oncology 9.8 (2013): 1097-1103. Source

Vitamin B9 Folate

Folate is a water-soluble B vitamin. Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression. Folic acid is important for managing HPV. Folate rich foods include dark green leafy vegetables (such as spinach, asparagus and Brussels sprouts), nuts and beans, and liver.(6) (7) (8) (9)

A daily serving of Papillex® contains the equivalent of 5oz of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus.

Science & Sources Behind This*
  • Calculation (400mcg*2) 800mcg. Source
  • 6 Bai, Li-Xia, et al. “Folate deficiency and FHIT hypermethylation and HPV 16 infection promote cervical cancerization.” Asian Pacific journal of cancer prevention: APJCP 15.21 (2013): 9313-9317. Source
  • 7 Moody, Michael, et al. “Folic acid supplementation increases survival and modulates high risk HPV-induced phenotypes in oral squamous cell carcinoma cells and correlates with p53 mRNA transcriptional down-regulation.” Cancer cell international 12.1 (2012): 1. Source
  • 8 Arthur, Anna E., et al. “Higher micronutrient intake is associated with human papillomavirus-positive head and neck cancer: a case-only analysis.” Nutrition and cancer 63.5 (2011): 734-742. Source
  • 9 Paul, Proma, Haripriya Vedantham, and V. Keerti. “Indian women with higher serum concentrations of folate and vitamin B12 are significantly less likely to be infected with carcinogenic or high-risk (HR) types of human papillomaviruses (HPVs).” International Journal of Women’s Health 2 (2010): 7-12. Source

Vitamin C

A powerful antioxidant; research studies conclude that individuals with higher Vitamin C levels better regulate HPV viral load, and decrease frequency of the development of further concerns.(10) (11) (12) Foods highest in Vitamin C include yellow bell peppers, guavas, dark green vegetables (especially kale and turnip greens), kiwi and broccoli. It is important that those concerned with HPV get enough vitamin C. For this reason, we have included it in the Papillex® formula.

A daily serving of Papillex® contains the equivalent of 1/2 yellow pepper, 1 guava or 2 cups of kale.

Science & Sources Behind This*
  • Calculation: (70mg*2 = 140mg) Source 1
  • 10 Nirmala, J. Grace, and R. T. Narendhirakannan. “Detection and genotyping of high-risk HPV and evaluation of anti-oxidant status in cervical carcinoma patients in Tamil Nadu State, India-a case control study.” Asian Pacific Journal of Cancer Prevention 12.10 (2011): 2689-2695. Source
  • 11 Esquenazi, David, et al. “The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR.” Brazilian journal of otorhinolaryngology 76.1 (2010): 78-84. Source
  • 12 Chen, Alyce A., et al. “Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.” Carcinogenesis 30.6 (2009): 977-981. Source

Camelia Sinensis

Camelia sinensis is a broad term for the types of shrubs and plants used to produce tea. Green tea has long been known as a powerful plant that stimulates the immune system.(13) Green tea is used topically for genital warts and cervical dysplasia. Orally, green tea intake has been associated with slowed progression and decreased risk through its powerful antioxidant effects.(14) This is why we’ve included green tea extract in our formula to help respond to HPV.

A daily serving of Papillex® contains the equivalent of 2.5 cups of green tea.

Science & Sources Behind This*
  • Calculation: 300 mg of polyphenols. One cup of green tea = 140mg polyphenols. Source
  • 13 Rosen, T. “Green tea catechins: biologic properties, proposed mechanisms of action, and clinical implications.” Journal of drugs in dermatology: JDD 11.11 (2012): e55-60. Source
  • 14 Wang YQ, Lu JL, Liang YR, Li QS. Suppressive effects of egcg on cervical cancer. Molecules. 2018 Sep;23(9):2334. Source

Vitamin E

Vitamin E has been shown through clinical studies to inhibit cancer cell growth and support the immune system through its powerful antioxidant capabilities.(15) Foods high in Vitamin E include: cooked spinach, almonds, roasted sunflower seeds, avocados and fish.

A daily serving of Papillex® contains the equivalent of 32 cups of cooked spinach, 3 cups of whole almonds, or 28 whole avocados.

Science & Sources Behind This*
  • Calculation: (60*2IU = 120IUs ): 1IU = 1 mg on average = 120mg Source 1 Source 2
  • 15 Kang, Tae Heung, et al. “Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects.” PloS one 9.7 (2014): e103562. Source


Selenium is an essential trace mineral. Individuals with cervical dysplasia have been reported to have deficient levels of selenium.(16) In recent animal studies, selenium has also been shown to regulate dysregulated cells.(17)

Selenium is a difficult nutrient to obtain, as many of our soils are depleted of this essential mineral. Foods that are generally higher in selenium include: brazil nuts, oysters, tuna and sunflower seeds.

Science & Sources Behind This*
  • Calculation: 60mcg*2 = 120 mcg, 50mcg per brazil nut Source
  • 16 Abulizi G, Zhang YY, Mijiti P, Li H, Abuduxikuer G, Cai J, Dong ZH, Naizhaer G, Yang XW, Maimaiti M, Abudurexiti G. Serum Se, Ni, and As are associated with HPV infection and CIN2+ among Uyghur women in rural China. BMC cancer. 2018 Dec;18(1):925. Source
  • 17 Tolen, Jennifer A., et al. “Selenium Attenuates HPV-18 Associated Apoptosis in Embryo-Derived Trophoblastic Cells but Not Inner Cell Mass In Vitro.” International journal of reproductive medicine 2015 (2015). Source


This powerful immune modulator has been used for centuries to promote resilience in the body. Recent studies have shown the herb’s impact on the growth of dysregulated cervical epithelial cells, regulating cell growth and reducing expression.(18)

Science & Sources Behind This*
  • 18 Lyu, Ling, et al. “Effects of Astragalus injection on cervical immortalized epithelial cell growth and its cell cycle regulation mechanism.” Journal of Hainan Medical University 22.4 (2016): 17-20. Source

Ganoderma Lucidum

The reishi mushroom has been celebrated for its properties for more than 2,000 years. Clinical studies have shown that the use of these mushrooms dramatically support the normal clearance rate of HPV, both vaginal and oral.(19) (20)

Science & Sources Behind This*
  • Calculation: 60mcg*2 = 120 mcg, 50mcg per brazil nut Source
  • 19 Donatini, Bruno. “Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial.” International journal of medicinal mushrooms 16.5 (2014). Source
  • 20 Hernandez-Marquez, Eva, et al. “Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes) on transformed cells by Human Papillomavirus.” International journal of medicinal mushrooms 16.2 (2014). Source